An incredible mystery was discovered by scientists from the Academy Sinica — how polysaccharides found in the mushroom Ganoderma Lucidum — Reishi activate the human immune system to fight cancer.
A team of scientists from the Genomic Research Center, Academia Sinica previously found that F3, raw extract polysaccharides containing fucose from mushroom Reishi, has the ability to stimulate the proliferation of various immunocyte and to increase the activity of NK cells.
The next results are published in the “Proceedings of the National Academy of Sciences, USA” and attracted much attention. Recent research by the team demonstrated that these polysaccharides, after being injected into mice, can induce antibodies to identify tumor-associated carbohydrate antigens on cancer cells and destroy them.
This work has started in Taipei from the group of Dr. Hsien-Yeh Hsu at the National University. When injected into mouse, F3 patient with lung cancer, it was found that it slows cancer’s growth, but the anticancer mechanism was not known.
In association with a research team led by Dr. Wong, Chi-Huey and Dr. Wu, Chung-Yi in genomic Research Center, Academia Sinica, was found that serums from mice that were immunized with F3 contain antibodies that recognize tumor antigens Globo H and related structures on them. Inhibition of tumor growth is directly related to the amount of this type of antibody.
Reishi mushroom’s ability to fight cancer is due to one ingredient consisted in this incredible mushroom — fucose. If you remove the fucose, the cancer fighting ability is greatly reduced.
Team Dr. Kuo-I Lin from genomic Research Center found that B1 immunocytes produce IgM antibodies to recognize Globo H and related molecules on it and destroy cancerous cells similar to the way that it makes the complement system.
Thanks to this team managed to prove the molecular mechanism of action of polysaccharides in Reishi mushroom and their anticancer activity.